Exchange 120ct by ALRI

Exchange 120ct by ALRI
Brand: ALR Industries ALR Industries
Product Code: 9492239366
Availability: 4
Primary Ingredient: Ursolic Acid
Other Ingredient: Plantanus Orientalis
Primary Use: Fat Loss
Other Use: Lean Muscle
Price: $70.99 $29.99
Qty:  
   - OR -   
SALE

Exchange 120ct by ALRI

Lose Weight Build Muscle Get Stronger

Exchange…Fat For Muscle?

Obviously there are few individuals on this planet that would say no to the opportunity to exchange fat for muscle. Enhancing the body’s ability to utilize fat stores as a source of calories usually means a decreased diet that reduces calorie intake to a point where less calories are ingested than the body burns daily. Unfortunately, with this low calorie environment comes a “catabolic environment” in which needed daily calories also come from the breaking down of lean tissue (like muscle and connective tissue). What if it was possible to use fat stores as a source of calories without losing lean tissue during low calorie dieting? Now, imagine a magic pill that allowed you to use fat calories to build and repair lean tissue without a reduced caloric intake?

ALRI Exchange

  • Increased muscle growth*
  • Greater bioavailability & targeted delivery*
  • Significant muscle catabolism inhibition*
  • Increased NO vasodilation*
  • Decreased fat stores*

It’s Been Done Already?

In an interesting study performed at The University of Iowa on mice (1), researchers found that a natural compound found in the waxy coating of apple peels had beneficial effects upon body composition. According to Dr. Christopher Adams and colleagues, the benefits appear to be due to the administration of the apple peel compound known as ursolic acid. The project started when Adams and colleagues researched and identified 63 genes that change in response to fasting. These genes are the same in both people and mice. Then the team quantified an additional 29 genes that change their expression in muscles tissue of people who are fasting and those with spinal cord injuries. Next step is obvious, the team of researchers evaluated over 1,300 small molecules eventually zeroing in on ursolic acid as a compound that might counteract muscle atrophy (muscle wasting).

Dr. Adams’ and colleague’s research findings showed:

  • The study showed that effects of ursolic acid on muscle in normal mice were accompanied by reductions in their body fat, fasting blood glucose, cholesterol and fats called triglycerides.
  • Ursolic acid inhibited muscle atrophy in fasting mice. However, without ursolic acid, fasting in mice reduced muscle weight by 9%. Providing fasting mice with dietary ursolic acid increased their muscle weight by 7%. Metformin had no effect on muscle atrophy in fasting mice.
  • Ursolic acid also induced muscle growth (hypertrophy) in normal mice. Mice on a diet containing ursolic acid had larger skeletal muscles and skeletal muscle fibers and increased grip strength compared to those on a normal diet

The researchers explained these results in the mice were initiated at the gene level and were due to enhanced insulin/IGF-1 signaling in muscle and to corrections in gene signatures associated with muscle atrophy in both humans and mice (1,3). Another in study (12) confirmed that ursolic acid activates peroxisome proliferator-activated receptor (PPAR)-α in vitro. Ursolic acid enhances the binding of PPAR-α to the peroxisome proliferator response element in PPAR-α-responsive genes, alters the expression of key genes in fat metabolism, significantly reducing intracellular triglyceride and cholesterol concentrations in hepatocytes. Thus, ursolic acid is a PPAR-α agonist that regulates the expression of lipid metabolism genes. Altering fat metabolism favorably at the genetic level appears to be one of the pathways by which ursolic acid reduces fat stores. In short, a very pro-lean-mass-gain/fat loss environment was induced.

Studied Benefits of Ursolic Acid:

  • Augmentation of lean muscle mass by way of increased sensitivity to IGF-1 and insulin as well as inhibition of atrogin-1 and MuRF1.
  • Increased muscle glycogen stores thus increase muscular recovery and performance potential.
  • Increased bone strength by enhancing IGF-1 activity and differentiation and mineralization of osteoblasts.
  • By inhibiting 11-bHSD-1 decreased visceral (abdominal) fat.
  • Decreased estrogen levels through aromatase inhibition.
  • By way of pancreatic inhibition of lipase and increased lipolysis in fat cells, decreased fat storage and increase fat burning.
  • Decreased conversion of blood sugar to fat by inhibition fatty acid synthase.
  • Decreased bad cholesterol and fat stores through the activation of PPAR.
  • Inhibition of inflammatory cytokins, IL-6, and COX-2 specifically.

So Now What?

Ursolic Acid (UA) is not a new compound to the performance nutrition world. The positive effects of this interesting compound have been studied for years in humans, mice, rats and other mammals. The results from this research have been impressive enough that UA has been part of the Chain’d Out® formula from the beginning. (UA is naturally occurring in the waxy coating on apples…we named the whole apple peel extract “AppleActiv™”). More recently UA has been sold as a stand-alone product in the performance nutrition industry. So why not just throw some in a capsule and swear it’s the find of the century?

But The Oral Bioavailability of Ursolic Acid is Less Than 1%...Oh My!

Can you really expect 100% of potential results from a compound when 99% + of the ingested dosage hits the toilet and less than 1% enters the body? Well, many ARE seeing and feeling positive results even with such poor oral bioavailability. Most researchers are seeking to overcome the poor oral bioavailability of ursolic acid seeking more dramatic results. Ingesting with fats may enhance its total bioavailability. Another far better option is to decrease gastric destruction so more stable ursolic acid is available for absorption in the small intestines. So what makes Exchange such a big deal?

Introducing the DRCaps™ Delivery System from Pfizer Pharmaceutical Capsule Division.

Naturally, we were pretty excited when research turned up an answer to the “results-thieving-poor-oral bioavailability-limiting-factor.” We have been able to significantly improve the dosage-to-results ratio of ursolic acid, and its cousin oleanic acid, through significantly improved oral bioavailable delivery without question. How? DRCaps™ prevent the stomach’s acidic environment from dissolving the Exchange capsule thus protect the sensitive structures of their contents, in this case, ursolic and oleanic acid. DRCaps™ deliver their whole pay-load into the small intestines where the PH is far more ingredient friendly. Exchange!

Okay, So Why Did We Add Oleanic Acid to Ursolic Acid?

One of the body’s primary recovery blockades is increased inflammation (4). In fact inflammation has recently been linked to the cause of many diseases (5) as well as decreased muscle mass and increased fat mass (6,7,8). Several studies have shown both ursolic and oleanic acid to be natural specific COX-2 Inhibitors (2,9) via down regulation of IL-6 and COX-2 itself. What does this mean to you? How much harder would you train and how much better would your perform if you had less or no joint, soft tissue or muscle pain?

Better Body Composition Due to Increased Insulin Sensitivity?

In other studies (10,11), both in vivo and in vitro, ursolic and oleanic acid have shown to increase Glut-4 receptor activity and up-regulation of tissue insulin sensitivity. This in itself makes ursolic and oleanic acid potentially powerful allies in lean mass augmentation as well as the fight against fat gain. Just saying…

Exchange: The next leap toward lean mass body re-compositioning and performance nutrition

 

 

Nutrition Facts

Serving Size 2 Capsules
Servings Per Container 60
 
Amount Per Serving
   Serving  % DV
Exchange Fat for Muscle Proprietary Matrix: 1045 mg   -  
 
Proprietary Blends
Exchange Fat for Muscle Proprietary Matrix:
Plantanus Orientalis Leaf Extract, Rosmarinus Officinalis Extract (providing Ursolic Acid, Oleanolic Acid), Piperine. (Average Ursolic Acid Per Serving: 245mg)
 
*percent Daily Values are based on a 2,000 calorie diet.
 

Ingredients: Vegetarian Hypromellose, Microcrystalline Cellulose, Modified Cornstarch, Magnesium Stearate, Silica. 

Directions

As a dietary supplement take two (2) capsules in the morning immediately prior to eating. Take two (2) capsules approximately 10-12 hours later immediately prior to eating. For best results, include some dietary fats in both meals immediately after consuming product.

Warnings

Not For Use By Individuals Under The Age Of 18. Do Not Use If Pregnant Or Nursing. This product is intended for use by healthy individuals only. Do not use if you have a medical condition or are taking any prescription medication. Consult a physician prior to using this product if you have any pre-existing medical condition including diabetes or hypoglycemia or if you take any glucose-lowering agents or other drugs or supplements that affect blood sugar. Do not exceed recommended dosage. Keep Out Of Reach Of Children. Read entire label prior to use. 

Research Information:

1. MCell Metab. 2011 Jun 8;13(6):627-38. mRNA expression signatures of human skeletal muscle atrophy identify a natural compound that increases muscle mass.

2. Cancer Res 2003;63:4375-4383. Published online August 7, 2003. Shishir Shishodia, Sekhar Majumdar, Sanjeev Banerjee, et al. Metalloproteinase 9, and Cyclin D1 Down-Regulation of Cyclooxygenase 2, Matrix Kinase and p65 Phosphorylation : Correlation with by Carcinogenic Agents through Suppression of I kBa Ursolic Acid Inhibits Nuclear Factor-kB Activation Induced

3. Bone. 2006 Dec;39(6):1331-42. Epub 2006 Aug 4. Dried plum prevents bone loss in a male osteoporosis model via IGF-I and the RANK pathway.

4. European Journal of Sport Science, Volume 8, Issue 5, 2008, Muscle damage, inflammation, and recovery interventions during a 3-day basketball tournament

5. Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk. Psychology, Carnegie Mellon University, Pittsburgh, PA 15213; bDepartment of Otolaryngology/ENT, Children’s Hospital of Pittsburgh, Pittsburgh, PA 15224; cDepartment of Psychology, University of British Columbia, Vancouver, BC, Canada V6T 1Z4; Departments of Psychiatry and Pathology, University of Pittsburgh

6. Kershaw, E. E.; Flier, J. S. (2004). "Adipose tissue as an endocrine organ". J Clin Endocrinol Metab 89 (6): 2548–2556. doi:10.1210/jc.2004-0395. PMID 15181022. Review.

7. Bastard J et al (2000). "Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss". J Clin Endocrinol Metab 85 (9): 3338–3342. doi:10.1210/jc.85.9.3338. PMID 10999830. http://jcem.endojournals.org/cgi/content/full/85/9/3338?ijkey=c94031a625120a7e59ea52e88137260e974cee3a.

8. Mohamed-Ali V et al (2001). "beta-Adrenergic regulation of IL-6 release from adipose tissue: in vivo and in vitro studies". J Clin Endocrinol Metab 86 (12): 5864–5869. doi:10.1210/jc.86.12.5864. PMID 11739453

9. J Nat Prod. 1998 Oct;61(10):1212-5. Ursolic acid from Plantago major, a selective inhibitor of cyclooxygenase-2 catalyzed prostaglandin biosynthesis.

10. Ren Fail. 2010;32(7):832-9. Synergistic antihyperglycemic effects between plant-derived oleanolic acid and insulin in streptozotocin-induced diabetic rats.

11. Biochem. J. (2007) 403, 243–250 (Printed in Great Britain) doi:10.1042/BJ20061123 243 Insulin-mimetic and insulin-sensitizing activities of a pentacyclic triterpenoid insulin receptor activator

12. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5876-80. Epub 2011 Aug 3. Ursolic acid is a PPAR-α agonist that regulates hepatic lipid metabolism.

13. Eur J Med Chem. 2008 Sep;43(9):1865-77. Evaluation of ursolic acid isolated from Ilex paraguariensis and derivatives on aromatase inhibition.

Q: I’ve heard that Exchange® is a ‘repartitioning agent” and helps increase muscle mass and decrease body fat…is that true?

A: You heard right. First let’s explain what a “repartitioning agent” is:

re·par·ti·tion [ree-pahr-tish-uh n, -per-]

noun

  • 1. distribution; partition.
  • 2. reassignment; redistribution.

verb (used with object)

  • 3. to divide up.
  • 4. to partition or subdivide again; reapportion; redistribute.

In simple terms, the compounds in Exchange® support the repartitioning of nutrients so what you eat, gets ‘reassigned or redistributed’ to your muscle tissue, not your body fat cells. Pretty cool, huh?

Here’s the summary from the Blind Placebo Medical Overview 4 Week Human Clinical Study by A. Human MD and Associates:

  • The Exchange® product group had an average increase in lean body mass of +3.23lbs. Versus The placebo group which had an average increase in lean body mass of +0.783lbs.† Exchange® group: 413%greater increase in lean mass.
  • The Exchange® product group had an average loss in fat mass of -5.0lbs. Versus The placebo group which had an average gain in fat mass of +0.583lbs. †Exchange® group: 857% greater decrease in fat mass. †

Q: Can women use Exchange®?

A: Yes, Exchange® is perfectly safe for women. As a matter of fact, in that same study mentioned above, Blind Placebo Medical Overview 4 week Human Clinical Study by A. Human MD and Associates, “In comparison, female subjects had near equivocal results to male subjects.”

Q: What is Ursolic Acid & what are the benefits?

A: Ursolic Acid (UA) is not a new compound to the performance nutrition world. The positive effects of this interesting compound have been studied for years in humans, mice, rats and other mammals. The results from this research have been impressive enough that UA has been part of the Chain’d Out® formula for over 4 years. (UA is naturally occurring in the waxy coating on apples…we named the whole apple peel extract “AppleActiv™”).

The studied benefits of Ursolic Acid include:

  • Augmentation of lean muscle mass by way of increased sensitivity to IGF-1 and insulin as well as inhibition of atrogin-1 and MuRF1.†
  • Increased muscle glycogen stores thus increase muscular recovery and performance potential.†
  • Increased bone strength by enhancing IGF-1 activity and differentiation and mineralization of osteoblasts.†
  • By inhibiting 11-bHSD-1 decreased visceral (abdominal) fat.†
  • Decreased estrogen levels through aromatase inhibition.†
  • By way of pancreatic inhibition of lipase and increased lipolysis in fat cells, decreased fat storage and increase fat burning.†
  • Decreased conversion of blood sugar to fat by inhibition fatty acid synthase.†
  • Decreased bad cholesterol and fat stores through the activation of PPAR.†
  • Inhibition of inflammatory cytokins, IL-6, and COX-2 specifically.†
 

†These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

NOT FOR USE BY INDIVIDUALS UNDER THE AGE OF 21. DO NOT USE IF PREGNANT OR NURSING. This product is intended for use by healthy individuals only. Do not use if you have a medical condition or are taking any prescription medication. Consult a physician prior to using this product if you have any pre-existing medical condition including diabetes or hypoglycemia or if you take any glucose-lowering agents or other drugs or supplements that affect blood sugar. Do not exceed recommended dosage.

Write a review

Your Name:


Your Review: Note: HTML is not translated!

Rating: Bad           Good

Enter the code in the box below:



Categories
Powered By OpenCart
sustevol.com © 2014

CR2